Burden of Comorbid Diseases in Patients with Hemophilia:

The Cross-Sectional Analysis of the Patient Reported Outcomes, Burden and Experiences (PROBE) Study

ASH 2017 (Atlanta, GA, December 9-12): Health status in patients with hemophilia (PWH) is affected by bleeding related complications, for instance, intermittent joint bleeding, hemophilic arthropathy and chronic pain. Older PWH are also found to have one or more additional diseases co-occurring with a primary disease or disorders (comorbid diseases) which have an effect on their health status. The aim of this study is to evaluate the burden of comorbid diseases in PWH.

All participants completed the 29-item Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire. The prevalence of comorbid diseases reported by the participants were calculated and compared to participants without bleeding disorders.

There were 1170 PWHs (Heme A: 84%; Heme B 16%) and 525 participants without bleeding disorders included in the analysis. The average age of participants was lower in PWHs group (34.2 vs 44.8 years). . With regards to severity of hemophilia 13.93% were mild, 17.81% were moderate and 66.27% were severe.

In PWHs, there was a higher prevalence of hepatitis B (6.2 times higher), hepatitis C (263 times higher), HIV (24.2 times higher), hypertension (2.5 times higher), angina/chest pain (2.2 times higher), seizure (8.6 times higher), arthritis (6.5 times higher) and gingivitis (3.2 times higher).

PWHs frequently reported hemophilia related diseases (hepatitis B, C and HIV infection and arthritis), when compared to participants without bleeding disorders. Moreover, PWHs had a higher prevalence of hypertension and gingivitis across all disease severity. These findings suggested that selective comorbid diseases assessment in PWHs should be incorporated in usual hemophilia care.