CDC Data Shows PWH Living Longer

Cardiovascular and Liver Disease Top HIV/AIDS As Most Common Causes of Death as Patients with Hemophilia Live Longer

THSNA 2016 (Chicago, April 14-16): Prior to factor concentrates, bleeding was the major cause of death in patients with hemophilia, with the median age at death of 25 years; factor concentrates reduced deaths increasing age at death to 57 prior to the HIV/AIDS epidemic. The Centers for Disease Control and Prevention (CDC) has been monitoring causes of death and ages of hemophilia patients for decades. In data presented at the Thrombosis and Hemostasis Society of North America (THSNA) meeting, CDC presented data looking at causes and age at death of patients with hemophilia from 1999 through 2010.  During this period, the death rate dropped by ~ 50%, from 0.15 per 100,000 males to 0.07/100,000 males, while at the same time the median age at death increased from 49 to 64 years.

HIV/AIDS is no longer the most common cause of death. The most common cause of death was related to cardiac disease (34.6%), followed by hepatitis/liver disease (29.3%) and HIV-related disease (27%). Compared to patients without hemophilia, hemophilia deaths are more likely to be related to bleeding, hepatitis/liver disease, HIV/AIDS, infection, and intracranial bleeding, and less likely caused by cancer, cardiac and cerebrovascular disease, injury/trauma, and mental disorders. This report highlights the continued success of interventions to decrease death among PWH, along with the increased median age at death over time. However, this report also highlights possible areas of future research in hemophilia, including monitoring trends in morbidities related to aging, such as cardiac and cerebrovascular disease.