The Effect of Joint Disease on Pain and Functional Impairment
Study: The Pain, Functional Impairment, and Quality of Life (P-FiQ) study
ASH 2015 (Orlando, December 5-8) Pain and functional impairment as a result of joint disease are very serious problems affecting adults with congenital hemophilia. The Pain, Functional Impairment, and Quality of Life (P-FiQ) study was designed to measure the impact of pain and functional impairment on quality of life (QoL) in adult patients with hemophilia. Data presented in an oral presentation at the American Society of Hematology (ASH) 2015 Annual Meeting describe 381 adult males with mild to severe hemophilia and a history of joint pain or bleeding enrolled from 15 US sites. During routine clinical care visits, participants completed a pain history and 5 patient reported outcome surveys and underwent an evaluation by a trained physical therapist. Most participants reported problems with mobility, usual activities, and pain/discomfort. The median (or middle) value on a 10 point pain scale (0=none, 10=worst) for worst pain in the last week was 6.0, least pain was 1.0 with an, average pain score of 3.0. Ankles were most frequently reported as the joints with the most pain. Scores for activities involving the lower extremities including lying/sitting/kneeling/standing, were higher than scores reflecting activities using the arms. About half of participants reported no physical activity in the prior week. Score for physical aspects of quality of life were lower than those for emotional ones. Overall, this study showed that pain that impacted physical function and quality of life were observed in adult patients with hemophilia. Further analyses are underway to link assessments of pain and function across different patient reported outcomes and hemophilia joint health score.
The PFiQ study (NCT01988532) was sponsored by Novo Nordisk Inc.